A Potential Ally Against Alzheimer’s


Highlights:


  • Urolithin A in pomegranates may aid Alzheimer’s treatment by enhancing memory and reducing inflammation

  • Animal studies suggest that urolithin A lowers plaque formation in the brain and improves learning and memory retention

  • While more human research is needed, incorporating pomegranates into the diet could potentially offer neuroprotective benefits

Can pomegranates help treat Alzheimer’s disease? New research suggests a substance found in pomegranates, Urolithin A, may improve memory and aid in dementia prevention and treatment (1✔ ✔Trusted Source
A review of pomegranate supplementation: A promising remedial avenue for Alzheimer’s disease

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).

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How Urolithin A May Help


  • Removes damaged cells: Urolithin A enhances the body’s ability to get rid of damaged cells, allowing for healthy cells to be produced.

  • Reduces inflammation: It reduces excessive inflammatory responses in the brain.

  • Improves mitochondrial function: It helps remove weak mitochondria (the powerhouse of the cell) from the brain, similar to NAD supplements. This is important because many patients with neurodegenerative diseases experience mitochondrial dysfunction.

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Impact on Memory

Animal studies have shown that urolithin A:


  • Lowers plaque formation in the brain

  • Leads to increased learning and memory retention

However, more human research is needed to confirm these findings.

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How to Get More Urolithin A

The best way to get more urolithin A is by eating foods that can help your gut bacteria produce it. These foods include:

Urolithin A Supplements

Some people may also consider taking urolithin A supplements. However, our bodies become less efficient at producing urolithin A as we age.

Supplementation may be appropriate, especially for older and middle-aged adults, but talk with your doctor first. Studies using supplemental urolithin A used doses ranging from 250mg to 1,000mg. Higher doses may cause adverse effects. Start with a lower dose (250mg) and increase slowly as needed.

This is a promising area of research, but more studies are needed. Talk to your doctor before taking urolithin A supplements.

Reference:

  1. A review of pomegranate supplementation: A promising remedial avenue for Alzheimer’s disease
    – (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10700657/)

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