In the UK-wide study, 419 people were monitored for NFPAs across 23 specialist sites. A team of endocrinologists led by Dr Niki Karavitaki from the University of Birmingham found that NFPAs were almost twice as likely to shrink or disappear by themselves (14% likelihood) as to grow (7.8% likelihood) within the first three years of monitoring. Among those tumours that grew, average (median) growth of tumours was 2mm, and eight participants’ tumours were surgically removed and only one of them had any visual impairment.
Dr Niki Karavitaki, Clinical Associate Professor in Endocrinology in the Institute of Metabolism and Systems Research at the University of Birmingham and last author of the paper said: “These data are the best picture that we have in the UK of how these common tumours progress over a period of three to five years. The results show that most people, who are often diagnosed with these tumours as part of an unrelated scan, don’t need annual check on these tumours with the majority of adenomas either remaining the same size or shrinking.”
Single Scan After 3 Years is Cost-Effective To Manage NFPAs
First author of the paper was Dr. Ross Hamblin, MD student at the University of Birmingham and the findings have led the research group, called the UK NFPA Consortium to suggest that clinical guidelines should be changed due to the low risk of these common tumours developing into a health risk for most people. The Consortium suggest that a single scan three years after initial detection would be a safe and more cost-effective way to manage NFPAs.
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Dr Karavitaki said: “At the moment, people are often being re-scanned on an annual basis during the first years from the initial detection of the tumour without a really clear clinical rationale, and our results show that for those with microadenomas those scans are unnecessary which can lead to space being freed up for other conditions.”
“Our recent survey of UK clinicians has found a significant variation in frequency of scans and we believe that on this research should be a strong steer that a more cost-effective approach is still safe for patients due to the very low risks involved.”
Reference :
- Natural history of non-functioning pituitary microadenomas – results from the UK NFPA consortium – (https://pubmed.ncbi.nlm.nih.gov/37345849/)
Source: Eurekalert
