Researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, conducted a study to figure out which MS lesion locations are associated with memory issues. The team, led by Isaiah Kletenik, MD, analyzed imaging and cognitive data from 431 people with MS enrolled in the Comprehensive Longitudinal Investigation of MS at Brigham and Women’s Hospital, or CLIMB study.
Researchers mapped white matter lesion locations from each person and tested associations between memory dysfunction and a memory circuit previously derived from strokes causing memory problems. The researchers also analyzed the MS lesion locations compared to large functional and structural brain atlases to identify unique MS memory circuits.
“In many neurologic diseases, we know what brain function will be disrupted based on the location of lesions, but in MS, the lesions are widespread making localization challenging,” Kletenik said.
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The team included researchers from the Brigham MS Center and from the Center for Brain Circuit Therapeutics led by Michael D. Fox, MD, PhD. Rohit Bakshi, MD, Bonnie Glanz, PhD, Charles Guttmann, MD, and Tanuja Chitnis, MD, collected neuroimaging and behavioral data on people with MS as part of large, ongoing studies at the Brigham MS Center. Dr. Bakshi and Dr. Guttmann developed an imaging pipeline to automatically segment MS lesions and Dr. Glanz worked with MS Center staff to perform cognitive testing for this study.
Reference :
- Multiple sclerosis lesions that impair memory map to a connected memory circuit – (https://link.springer.com/article/10.1007/s00415-023-11907-8)
Source: Eurekalert
