These findings were revealed by researchers at the University of Colorado Anschutz Medical Campus and at Hospital Rosales in San Salvadora and published in the journal,
An ongoing epidemic of chronic kidney disease has been observed among manual laborers in hot agricultural communities throughout the world, including along the Pacific coast of Central America, India, and Sri Lanka. While heat stress and climate change have contributed to this epidemic, researchers have identified
“To date, there are no studies we are aware of that have identified a toxicant that can cause chronic kidney disease which is actually present in kidney tissues of patients suffering from this unknown disease,” says Jared Brown, PhD, professor at the University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences and one of the senior authors.
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“These data provide an important clue to the mystery and suggest that in addition to heat stress from climate change that toxicants from sugarcane ash could be contributing to the disease.”
The study suggests the disease could result from exposure to sugarcane ash, which contains amorphous silica nanoparticles. This process may also be linked to people who work in rice paddies, as the burning of the rice paddies, which is also commonly done, can also lead to the release of silica-containing ash.
“While this data is preliminary, we can determine that the burning of sugarcane may not only be contributing to climate change, but it may have a role in the epidemic that has been affecting agricultural workers,” says Richard Johnson, MD, CU Anschutz School of Medicine professor and one of the senior authors.
“This disease is identified as one of the first newly recognized diseases resulting specifically from a warming climate. Now we know toxicants are also involved. Hopefully, this work will spur efforts to focus on sugarcane burning as a potential risk factor for the development of this mysterious kidney disease in workers and people who live adjacent to sugarcane fields.”
Reference :
- Silica Nanoparticles and Mesoameriacan Nephropathy: A Case Series – (https://www.ajkd.org/article/S0272-6386(23)00802-8/fulltext)
Source: Eurekalert
