You may be familiar with the gut microbiome’s impact on overall health. Surprisingly, a similar principle applies to the semen microbiome, which may significantly influence sperm parameters and contribute to improved male fertility.

Considering recent studies highlighting the microbiome’s significance in overall human health, researchers investigated the semen microbiome to understand its potential impact on male infertility. Exploring the functions of these microorganisms in semen could potentially pave the way for developing treatments targeted at rectifying any issues with sperm parameters.

Lactobacillus iners and Its Detrimental Impact on Male Fertility

The study found that one microbe in particular, Lactobacillus iners, may have a direct negative impact on male fertility. Previous research revealed that Lactobacillus iners can preferentially produce L-lactic acid, potentially leading to a pro-inflammatory environment locally, which could adversely affect sperm motility. The study authors point out that existing research has hinted at the link between this microbe and fertility, but most of the literature pertains to the vaginal microbiome and female factors. This is the first study to report a negative association between the microbe and male-factor fertility.

Researchers also discovered that three types of bacteria in the Pseudomonas group were present in patients with both normal and abnormal sperm concentrations. Microbes called Pseudomonas fluorescens and Pseudomonas stutzeri were more common in patients with abnormal sperm concentrations, while Pseudomonas putida was less common in samples with abnormal sperm concentrations. However, the findings indicate that not every member of the same closely related group may affect fertility in the same way, whether positively or negatively. In other words, even closely related microbes may not always have the same direct correlation to fertility.

“There is much more to explore regarding the microbiome and its connection to male infertility,” said Vadim Osadchiy, a resident in the Department of Urology at UCLA and the lead author of the study. “However, these findings provide valuable insights that can lead us in the right direction for a deeper understanding of this correlation.”

Source-Eurekalert