“We knew from prior studies that patients with multiple myeloma and diabetes have lower survival rates,” explained Urvi Shah, MD, a multiple myeloma specialist at Memorial Sloan Kettering Cancer Center. “But what we did not know is how these outcomes differ between races. Diabetes is much more common in Black individuals versus white individuals, and we wanted to understand whether this difference may play a role in health outcomes among patients with both conditions.”

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Researchers conducted a retrospective study, collecting data from electronic health care records of 5,383 patients with multiple myeloma from two academic medical centers: Memorial Sloan Kettering Cancer Center and Icahn School of Medicine at Mount Sinai. Fifteen percent of patients included had a diabetes diagnosis (12% of white and 25% of Black patients).

Evaluating the Overall Outcome of Diabetes with Blood Cancer in Mouse Model

Dr. Shah added that generally, one’s risk of developing diabetes increases with age. Study findings also show that overall survival decreases with age. Notably, however, in this cohort, diabetes was 50% more prevalent among Black patients 45-60 years old than white patients over 60 years old. Younger patients may tolerate multiple myeloma treatments better than older individuals, and these differences could explain some of the racial differences investigators observed in survival outcomes.

When investigating the mechanisms behind these findings, Dr. Shah and colleagues observed that in genetically engineered mouse models, multiple myeloma tumors grew more rapidly in non-obese diabetic mice than in non-diabetic controls.

After studying the biological mechanisms underlying tumor growth in these mice, researchers found that an insulin-related signal was over-activated in the diabetic mice, leading them to believe that higher insulin levels associated with diabetes may accelerate cancer growth.

“In my own practice, I work with many patients with both multiple myeloma and diabetes. And usually treating multiple myeloma involves many rounds of chemotherapy,” said Dr. Shah. “But this study suggests that we may also improve patient outcomes further by treating diabetes at the same time.”

Going forward, Dr. Shah and colleagues aim to identify therapies that stop both the development of multiple myeloma and the overactive insulin signaling pathway they believe may be prevalent in patients with multiple myeloma and diabetes. Dr. Shah is also investigating how modifiable risk factors like the microbiome and one’s diet can be altered to improve cancer outcomes.

Reference :

1. Diabetes May Accelerate Blood Cancer Growth, Yet Survival Outcomes Differ by Race – (https://www.mountsinai.org/about/newsroom/2023/diabetes-may-accelerate-blood-cancer-growth-yet-survival-outcomes-differ-by-race)

Source: Eurekalert