Regularly feeding children peanuts from infancy to age five decreased the likelihood of developing a peanut allergy in adolescence by 71%, persisting even when dietary habits regarding peanuts varied over the years (1^✔ ✔Trusted Source
AAP Clinical Report Highlights Early Introduction of Peanut-based Foods to Prevent Allergies

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These new findings firmly establish that early introduction of peanuts into babies’ diets effectively prevents peanut allergies in the long term.

Early Introduction of Peanuts Reduces Allergy Risk

Lead investigator Professor Gideon Lack from King’s College London said: “Decades of advice to avoid peanuts has made parents fearful of introducing peanuts at an early age. The evidence is clear that early introduction of peanuts in infancy induces long term tolerance and protects children from allergy well into adolescence. This simple intervention will make a remarkable difference to future generations and see peanut allergies plummet.”

Results from the LEAP-Trio trial are published today in the NEJM Evidence by researchers from King’s College London and sponsored and co-funded by the US National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID).

Peanut allergy is rising in Western countries. The prevalence of peanut allergy is about 2% in young children in North America, UK, Western Europe, and Australia. For some, even small amounts of peanuts can lead to a life-threatening allergic reaction. This, as well as conflicting advice, has made parents and caregivers fearful of introducing peanuts into diets.

Long-Term Benefits of Early Peanut Consumption

The new research findings come from the LEAP-Trio study, building on the results of the Learning Early About Peanut Allergy (LEAP) clinical trial. In the first trial, half of the participants were asked to regularly consume peanuts from infancy until age 5 years, while the other half were asked to avoid peanuts during that period. Researchers found that early introduction of peanuts reduced the risk of peanut allergy at age 5 by 81%.

The investigators followed up both groups from age 6 to age 12 or older. In that period, children could choose to eat peanuts in whatever amount and frequency they wanted. They found that 15.4% of participants from the early childhood peanut-avoidance group and 4.4% from the early childhood peanut-consumption group had peanut allergy at age 12 or older. These results show that regular, early peanut consumption reduces the risk of peanut allergy in adolescence by 71% compared to early peanut avoidance.

Professor George Du Toit, Co-Lead Investigator from King’s College London said: “This is a safe and highly effective intervention which can be implemented as early as 4 months of age. The infant needs to be developmentally ready to start weaning and peanut should be introduced as a soft pureed paste or as peanut puffs.”

The researchers also found that although participants in the LEAP peanut-consumption group ate more peanuts throughout childhood than the other participants overall, the frequency and amount of peanut consumed varied widely in both groups and included periods of not eating peanuts. This shows that the protective effect of early peanut consumption lasts without the need to consistently eat peanut products throughout childhood and early adolescence.

The LEAP-Trio study team tested the adolescents for peanut allergy primarily through an oral food challenge. This involved giving participants gradually increasing amounts of peanuts in a carefully controlled setting to determine if they could safely consume at least 5 grams of peanuts, the equivalent of more than 20 peanuts. The study team also surveyed participants about their recent patterns of peanut consumption and verified the self-reports through measurements of peanut in dust from participants’ beds, a technique previously validated by LEAP investigators.

Professor Lack, who is the Head of the Children’s Allergy Service at Guy’s and St Thomas’ NHS Foundation Trust, added: “Early consumption of peanuts will prevent more than 100,000 new cases of peanut allergy every year worldwide.”

Reference:

1. AAP Clinical Report Highlights Early Introduction of Peanut-based Foods to Prevent Allergies – (https://www.healthychildren.org/English/news/Pages/Early-Introduction-of-Peanut-based-Foods-to-Prevent-Allergies.aspx)

Source-Medindia