Although nucleotide drugs offer advantages in treating tumors and other diseases, they often suffer from a poor efficiency of crossing the blood vessels and entering the tumor tissue, where their targets reside. This problem greatly limits their clinical applicability and efficacy.
“Our system demonstrates a good ability to deliver more ASOs into both primary tumor tissue and bone metastases — which is the primary site for prostate cancer metastasis,” said Pang, an assistant professor in the College of Pharmacy and a member of the Masonic Cancer Center.
“This further translates into a significant improvement of ASO efficacy to inhibit the growth of primary tumor and bone metastases. We expect this system to become a universal carrier system, to improve the clinical efficacy of ASOs and other nucleotide drugs.”
Findings of the study:
Source: Medindia