FACT OR FAKED: Is Cannabis Anti-inflammatory?

Acute, chronic, or auto-inflammatory diseases that might impair organ function frequently result in inflammation. Although cannabis (Cannabis sativa) has been used for thousands of years to alleviate inflammation, there is currently a lack of scientific evidence that supports its use in contemporary medicine. In vitro, as well as in pre-clinical and clinical trials, it has been reported in previous investigations that cannabis extracts and inflorescence decrease inflammatory reactions. The endocannabinoid system (ECS), which regulates immune system function, has a role in a number of chronic inflammations.

Endocannabinoids generated from arachidonic acid, cannabinoid receptor types 1 and 2 (CB1 and CB2), and enzymes involved in endocannabinoid metabolism make up this system. Numerous additional biomolecules, including terpenes and flavonoids, as well as a significant number of phytocannabinoids, are also produced by cannabis.

Numerous phytocannabinoids, such as 9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabigerol (CBG), demonstrate anti-inflammatory efficacy in a variety of experimental models, both in vitro and in vivo. By triggering multiple signaling pathways, these phytocannabinoids may bind to ECS and/or other receptors and alleviate a number of inflammatory-related diseases. It has been shown that phytocannabinoids and terpenes work in harmony with one another. By choosing the most active plant compounds (API) and removing some of the rest of the extract, cannabis activity can be increased. Additionally, cannabis extracts may one day be mixed with pharmaceuticals to lessen inflammation.

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