Hence, it is vital to identify the genes that trigger an increased risk of aneurysms in adults. The study team found that a specific gene PPIL4 is responsible for creating blood vessels in the developing vertebrate brain.
On further analyzing over 300 genomes of the patients with intracranial aneurysms, it was revealed that there was a significant increase of PPIL4 mutations among these people when compared to the general population.
The study thereby offers a new window to look into the disease that is through developmental defects in the gene.
“Studies like ours not only provide a genetic and mechanistic window into disease pathogenesis but present a remarkable potential for new pathways in IA screening, early diagnosis, and treatment,” says Ketu Mishra-Gorur, a research scientist at the Yale School of Medicine.
Source: Medindia
