The migraine pain often worsens with movement or activity, and it affects more than one in ten people. It affects more than 12% of the world’s population.
says Dr. Matthew Panizzon, the principal investigator of the study, also based at the UC San Diego School of Medicine.
The study for the first time reveals the discrepancies in genetic and environmental factors that may further trigger the migraine risk among women.
Nearly 51,872 individuals (from prior Swedish Twin Registry studies) were enrolled in the present study based on criteria of the International Headache Society Classification of Headache Disorders.
Prenatal Factors in Migraine
The study examined various genetic factors that were involved to drive the migraine risk among the opposite-sex twin in uterofemales and males.
It was found that prenatal environment factors hold the potential to underwrite the migraine risk in later life. In addition, the risk also differs between females and males.
“We are the first to show that females with a male co-twin have a higher risk of migraine compared to females with a female co-twin, suggesting that prenatal factors, possibly relating to in utero hormone levels, may contribute to migraine risk. We are also the first to present evidence that genetic factors related to migraine risk may be different between females and males,” says Morgan Fitzgerald, lead author of the study, from the University of California, San Diego School of Medicine.
Targeted Treatment for Migraine
The study findings thereby lay out differences that contribute to migraine risk among opposite genders.
These data may further help for improved clinical care, along with effective and targeted treatment options against the devastating disease migraine.
“Unfortunately, age at onset was not available in the Swedish Twin Registry data. In fact, most studies do not ask individuals when their migraine attacks first start. In the future, we hope to examine how age at migraine onset coincides with the timing of critical hormonal events like puberty,” says Fitzgerald.
References:
- Sex Differences in Migraine: A Twin Study
– (https://www.frontiersin.org/articles/10.3389/fpain.2021.766718/full) - Hormone exposure in the womb potentially linked to migraine risk in later life
– (https://medicaldialogues.in/obstetrics-gynaecology/news/hormone-exposure-in-the-womb-potentially-linked-to-migraine-risk-in-later-life-85783) - Hormone exposure in the womb potentially linked to migraine risk in later life
– (https://blog.frontiersin.org/2021/12/16/hormone-exposure-in-the-womb-potentially-linked-to-migraine-risk-in-later-life/)
Source: Medindia
