“In brain development, important transcription factors, like Vsx2, and many others, are often expressed in different parts of the developing brain at different times but in a precisely orchestrated way. We wanted to better understand how this complicated dance of expression is controlled where the gene is turned on at one moment in one cell type, then turned off in another and later activated in a different region completely.” “When you can fully understand how one of these modular super-enhancers works, you can go globally to all the super-enhancers with a framework to understand them more broadly,” says corresponding author Michael Dyer, PhD, St. Jude department of developmental neurobiology chair and Howard Hughes Medical Institute investigator.

Source: Medindia