A session at this year’s Annual Meeting of the European Association for the Study of Diabetes will explore the latest data on the concept of metabolically healthy obesity (MHO) – more commonly known by the public as
. Professor Matthias Blüher, University of Leipzig, Leipzig and Helmholtz Center, Munich, Germany will explain how we define MHO and ask if it can really be described as healthy (
).
Estimates suggest a different prevalence of MHO in men and women, with women living with obesity more likely to have MHO (7-28%) than men (2-19%). At the other end of the spectrum, around half of people living with obesity have at least 2 complications. For a given total body fat mass, people with MHO have lower liver fat mass (than expected for the BMI and total fat mass).
Prof Blüher will discuss that is how the adipose tissue behaves in people with obesity, rather than their body-mass index, which will determine whether or not their obesity is MHO. In people with adipocytes (fat-storing cells) that are of normal size, those people are less likely to display the complications of obesity – whereas in people with enlarged adipocytes and inflamed adipose tissue, these cells are more likely to exhibit traits such as insulin resistance that lead to metabolic complications.
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And the way that we store fat is likely key to whether or not obesity can be described as MHO. “When people with obesity have fat stored viscerally, or internally around their organs (such as in the liver), the data show that these people are much more likely to develop type 2 diabetes than those who store fat more evenly around their body,” says Prof Blüher.
Do Not be Deceived with Metabolically Healthy Obesity – Track your Risk Factors Too!
He goes on to explain that in people with adipose tissue dysfunction, this can lead to damaged tissue, fibrosis, and secretion of pro-inflammatory and adipogenic molecules that subsequently contribute to end-organ damage. As an example, adipokines (fat-released hormones) may act directly on cells of the vascular system and lead to atherosclerosis. In addition, metabolites such as fatty acids may impair the function of the liver or insulin-producing cells in the pancreas.
In conclusion, there are people with obesity who do not exhibit cardio-metabolic complications at a certain point in time. In the past, the diagnosis of MHO frequently led to a low priority for obesity treatment. This concept has been challenged because recent data suggest that the term metabolically healthy obesity is misleading.
He concludes: “Even in the absence of other cardiometabolic risk factors, increased fat mass and adipose tissue dysfunction contribute to a higher risk of type 2 diabetes and cardiovascular diseases. Therefore, weight management and recommendations for weight loss are still important for people living with metabolically healthy obesity.”
Reference :
- Metabolically healthy obesity: facts and fantasies – (https://www.jci.org/articles/view/129186)
Source: Eurekalert
