#SecondBooster #BA.2

Will a fourth dose have any added value? What is the efficacy of the fourth dose against Omicron? Let’s find out what we have learned about the fourth dose so far and if we have reached the maximal effect that the current version of the vaccine can offer.

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Disclaimer:

This video is Dr. Hong’s interpretation and summary of publically available scientific information
This video is not intended to serve as any advice regarding the treatment, prevention, and diagnosis of any diseases
Dr. Hong has no connections and receives no monetary compensation from any pharmaceutical companies and government.
This video is for educational purposes only.

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To learn more:
Can the Omicron BA.2 be the end? Transmissibility, Immunity Escape, Natural Immunity & Severity
https://youtu.be/UlLfLRiBSSM

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Source References:

BA.2 makes up 23.1% of all US COVID-19 variants
https://www.newsnationnow.com/health/coronavirus/ba-2-makes-up-23-1-of-all-us-covid-19-variants/

Experts fear COVID-19 cases in the United States will rise
https://abcnews.go.com/Health/covid-cases-predicted-rise-coming-weeks-ba2-variant/story?id=83501592

Pfizer CEO said fourth COVID-19 short is necessary
https://www.cbsnews.com/news/covid-vaccine-fourth-dose-booster-pfizer-ceo-albert-bourla/

Moderna Seeks FDA Authorization for Fourth Dose of COVID-19 Shot for All Adults
https://time.com/6158586/moderna-fourth-covid-19-vaccine-booster/

Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance
https://www.cdc.gov/mmwr/volumes/71/wr/mm7107e2.htm

Waning immune response after the third dose
https://www.nejm.org/doi/suppl/10.1056/NEJMc2202542/suppl_file/nejmc2202542_protocol.pdf

Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron
https://www.nejm.org/doi/full/10.1056/NEJMc2202542

Supplemental Data
https://www.nejm.org/doi/suppl/10.1056/NEJMc2202542/suppl_file/nejmc2202542_appendix.pdf

Third BNT162b2 Vaccination Neutralization of SARS-CoV-2 Omicron Infection
https://www.nejm.org/doi/full/10.1056/NEJMc2119358

Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00089-9/fulltext

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
https://www.nejm.org/doi/full/10.1056/nejmoa2022483

Omicron BA.2 sub-variant more infectious but no more severe – Africa CDC
https://www.reuters.com/business/healthcare-pharmaceuticals/omicron-ba2-sub-variant-more-infectious-no-more-severe-africa-cdc-2022-02-24/

Omicron subvariant BA.2 more infectious than ‘original’, Danish study finds
https://www.reuters.com/business/healthcare-pharmaceuticals/omicron-subvariant-ba2-more-infectious-than-original-danish-study-finds-2022-01-31/

Second COVID-19 booster shot does little to stop omicron, study finds
https://www.nny360.com/news/publicservicenews/second-covid-19-booster-shot-does-little-to-stop-omicron-study-finds/article_77984be6-8484-5104-b4ac-945f8ab98a74.html

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