When remdesivir penetrates inside the cell, five steps occur where an intermediate substance is formed from remdesivir ¡V a remdesivir metabolite with the somewhat unwieldy name
that plays the significant role of virostatic agent.
‘Second possible effective mechanism of remdesivir is discovered. The drug metabolite GS-441524 binds to the SARS-CoV-2 protein nsP3 that serves as a potential for drug development to combat numerous other viruses.’
The Virostatic Role of Remdesivir Metabolite – GS-441524
This GS-441524 executes its role by targeting a SARS-CoV-2 protein called nsP3 as per a study at the Institute for Pharmaceutical Chemistry at Goethe University Frankfurt. nsP3 is a multifunctional protein, whose tasks include suppressing the host cell’s defence response.
The host cell is not helpless in the face of a virus attack, but activates inflammatory mechanisms, among other things, to summon the aid of the cell’s endogenous immune system . nsP3 helps the viruses suppress the cell’s calls for help.
“GS-441525 inhibits the activities of an nsP3 domain which is important for the reproduction of viruses, and which communicates with human cellular defence systems. Our structural analysis shows how this inhibition functions, allowing us to lay an important foundation for the development of new and more potent antiviral drugs – effective not only against SARS-CoV-2. The target structure of GS-441524 is very similar in other coronaviruses, for example SARS-CoV and MERS-CoV, as well in a series of alphaviruses, such as the chikungunya virus. For this reason, the development of such medicines could also help prepare for future virus pandemics,” says Professor Stefan Knapp, head of the study at the Institute for Pharmaceutical Chemistry at Goethe University Frankfurt.
Source: Medindia
