{"id":117047,"date":"2024-08-23T16:35:02","date_gmt":"2024-08-23T16:35:02","guid":{"rendered":"https:\/\/rochellesthrezrs.com\/a-new-pathway-for-bacterial-invasion\/"},"modified":"2024-08-23T16:35:02","modified_gmt":"2024-08-23T16:35:02","slug":"a-new-pathway-for-bacterial-invasion","status":"publish","type":"post","link":"https:\/\/rochellesthrezrs.com\/a-new-pathway-for-bacterial-invasion\/","title":{"rendered":"A New Pathway for Bacterial Invasion"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<div class=\"report-content hightlightcontent\"><b>Highlights:<\/b><\/p>\n<ul class=\"group-list punch-points\">&#13;<\/p>\n<li><i>Salmonella<\/i> uses bioelectric signals in the gut to find weak spots for infection<\/li>\n<p>&#13;<\/p>\n<li>The bacteria target specific areas like the FAE using this electric guidance<\/li>\n<p>&#13;<\/p>\n<li>This discovery could lead to new approaches in preventing and treating chronic gut disorders<\/li>\n<\/ul>\n<\/div>\n<p><i>The gut is more than a battlefield; it&#8217;s a complex system where even electricity plays a role in health and disease.<\/i><br \/>\n In the intricate landscape of the <a href=\"https:\/\/www.medindia.net\/news\/study-shows-how-human-gut-microbes-could-make-processed-foods-healthier-190820-1.htm\" alt=\"Study Shows How Human Gut Microbes Could Make Processed Foods Healthier\" title=\"Study Shows How Human Gut Microbes Could Make Processed Foods Healthier\" target=\"_blank\" class=\"hlink\" rel=\"noopener\">human gut<\/a>, harmful bacteria like Salmonella manage to invade and cause diseases, even though they are vastly outnumbered by beneficial microbes and immune cells (<span class=\"src-tooltip\">1<span class=\"ref-tick\"><sup>\u2714<\/sup><\/span> <span class=\"src-tooltip-text\" id=\"third-src-tooltip-text\"><span class=\"assign\">\u2714<\/span>Trusted Source<br \/><span class=\"refblack\">Gut epithelial electrical cues drive differential localization of enterobacteria<\/span><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41564-024-01778-8\" target=\"_blank\" rel=\"noopener noreferrer\">Go to source<\/a><\/p>\n<p><\/span><\/span>).<\/p>\n<p>Recent research conducted by a team at <i>UC Davis Health<\/i> has uncovered a novel mechanism that these pathogens use to navigate and breach the gut&#8217;s defenses, shedding light on how they find entry points to infect the body. This groundbreaking study, published in <i>Nature Microbiology<\/i>, explores the role of bioelectricity in guiding bacteria like Salmonella to these vulnerable areas.<\/p>\n<p><center><\/p>\n<p>Advertisement  <!-- rwd-common-top -->      <\/p>\n<p><\/center><\/p>\n<h2> Challenge of Bacterial Invasion <\/h2>\n<p>Every year, <i>Salmonella<\/i> causes approximately 1.35 million illnesses and 420 deaths in the United States alone. For these bacteria to infect a host, they must cross the gut lining, a task that involves overcoming a multitude of protective barriers. Upon entering the intestines, <i>Salmonella<\/i> faces a daunting environment filled with over 100 trillion commensal bacteria. Yet, they succeed in finding weak points in the gut lining where they can infiltrate and cause infection.<center><\/p>\n<p>Advertisement  <!-- rwd-common-middle -->      <\/p>\n<p><\/center><\/p>\n<h2> New Discovery: Bioelectricity in the Gut <\/h2>\n<p>The research team at <i>UC Davis Health<\/i>, led by Yao-Hui Sun, a scientist affiliated with the Departments of Internal Medicine, Ophthalmology and Vision Science, and Dermatology, focused on understanding how <i>Salmonella<\/i> navigates the gut&#8217;s complex structure. Their study revealed that <i>Salmonella<\/i> detects bioelectric signals within the gut, which guide them toward specific areas where they can enter the body. This process, known as galvanotaxis or electrotaxis, is a type of cell movement in response to electric fields.<\/p>\n<p>The gut epithelium, which lines the intestines, consists of different types of cells, including absorptive enterocytes and M cells. The latter are part of the follicle-associated epithelium (FAE) and play a crucial role in the <a href=\"https:\/\/www.medindia.net\/health-press-release\/how-birm-is-balancing-immune-systems-677023-1.htm\" alt=\"How BIRM Is Balancing Immune Systems\" title=\"How BIRM Is Balancing Immune Systems\" target=\"_blank\" class=\"hlink\" rel=\"noopener\">immune system<\/a> by sampling antigens. The study found that <i>Salmonella<\/i> bacteria are attracted to the electric fields present in the FAE, allowing them to target this area as an entry point into the host.<\/p>\n<p><center><\/p>\n<p>Advertisement  <!-- rwd-common-bottom -->      <\/p>\n<p><\/center><\/p>\n<h2> Differential Responses of Bacteria to Bioelectricity <\/h2>\n<p>Interestingly, the study also observed that not all bacteria respond to bioelectric fields in the same way. While <i>Escherichia coli (<a href=\"https:\/\/www.medindia.net\/news\/common-antibiotics-to-fight-resistant-e-coli-186050-1.htm\" alt=\"Common Antibiotics to Fight Resistant E. Coli\" title=\"Common Antibiotics to Fight Resistant E. Coli\" target=\"_blank\" class=\"hlink\" rel=\"noopener\">E. coli<\/a>)<\/i>, a harmless strain, tends to cluster near the villi in the gut, <i>Salmonella<\/i> is drawn to the FAE. This suggests that <i>Salmonella<\/i> specifically exploits the bioelectric field configuration in the gut to its advantage, bypassing other areas and focusing on the FAE to invade the host.<\/p>\n<h2> Chronic Diseases and Bioelectric Guidance System <\/h2>\n<p>The discovery of this bioelectric guidance system not only advances our understanding of bacterial infections but also has potential implications for chronic conditions like <a href=\"https:\/\/www.medindia.net\/news\/inflammatory-bowel-disease-may-show-up-before-the-biopsy-result-210656-1.htm\" alt=\"Inflammatory Bowel Disease May Show Up Before the Biopsy Result\" title=\"Inflammatory Bowel Disease May Show Up Before the Biopsy Result\" target=\"_blank\" class=\"hlink\" rel=\"noopener\">Inflammatory Bowel Disease<\/a> (IBD). <\/p>\n<p>IBD is believed to be caused by an abnormal immune response against commensal bacteria, and this study raises the possibility that abnormal bioelectric activities in the gut could be linked to the development of such diseases. Further research could lead to new strategies for preventing and treating bacterial infections and chronic gut disorders.<\/p>\n<p>This highlights a previously unknown aspect of bacterial pathogenesis, emphasizing the role of bioelectricity in guiding pathogens to their target sites in the gut. As researchers continue to explore this new frontier, the findings could pave the way for innovative approaches to combating bacterial infections and managing chronic gastrointestinal diseases.<\/p>\n<p><b>Reference:<\/b><\/p>\n<ol class=\"list order-num\">&#13;<\/p>\n<li>Gut epithelial electrical cues drive differential localization of enterobacteria &#8211; <span class=\"breaktext\">(https:\/\/www.nature.com\/articles\/s41564-024-01778-8)<\/span><\/li>\n<\/ol>\n<p><\/p>\n<p>Source-Medindia<\/p><\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.medindia.net\/news\/healthwatch\/gut-bioelectricity-a-new-pathway-for-bacterial-invasion-216931-1.htm\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Highlights: &#13; Salmonella uses bioelectric signals in the gut to find weak spots for infection &#13; The bacteria target specific areas like the FAE using this electric guidance &#13; This discovery could lead to new&hellip;<\/p>\n<p><a class=\"excerpt-readmore\" href=\"https:\/\/rochellesthrezrs.com\/a-new-pathway-for-bacterial-invasion\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":117048,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-117047","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anxiety","odd"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/rochellesthrezrs.com\/wp-content\/uploads\/2024\/08\/bioelectric-pathway-of-salmonella-in-the-gut.jpg?fit=300%2C250&ssl=1","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/posts\/117047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/comments?post=117047"}],"version-history":[{"count":0,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/posts\/117047\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/media\/117048"}],"wp:attachment":[{"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/media?parent=117047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/categories?post=117047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/tags?post=117047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}