{"id":122674,"date":"2024-10-11T23:54:33","date_gmt":"2024-10-11T23:54:33","guid":{"rendered":"https:\/\/rochellesthrezrs.com\/diabetic-kidney-disease-new-insights-revealed\/"},"modified":"2024-10-11T23:54:33","modified_gmt":"2024-10-11T23:54:33","slug":"diabetic-kidney-disease-new-insights-revealed","status":"publish","type":"post","link":"https:\/\/rochellesthrezrs.com\/diabetic-kidney-disease-new-insights-revealed\/","title":{"rendered":"Diabetic Kidney Disease: New Insights Revealed"},"content":{"rendered":"<p> <br \/>\n<\/p>\n<div>\n<div class=\"img-responsive page-image top-content-picture\" style=\"float:left; padding-left:10px;padding-right:20px;\"><img data-recalc-dims=\"1\" fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/images.medindia.net\/health-images\/1200_1000\/antibody-response-to-kidney-transplant.jpg?resize=1150%2C958&#038;ssl=1\" width=\"1150\" height=\"958\" border=\"0\" alt=\"Diabetic Kidney Disease: New Insights Revealed\" title=\"Diabetic Kidney Disease: New Insights Revealed\" itemprop=\"contentUrl representativeOfPage\" class=\"rwd-img\" data-pin-description=\"Diabetic Kidney Disease: New Insights Revealed\" data-lazy=\"\"\/><\/div>\n<p>Diabetic kidney disease, a serious complication of diabetes, is the leading cause of chronic kidney disease and kidney failure globally. This condition results in damage to the kidneys, affecting both their structure and function.  (<span class=\"src-tooltip\">1<span class=\"ref-tick\"><sup>\u2714<\/sup><\/span> <span class=\"src-tooltip-text\" id=\"third-src-tooltip-text\"><span class=\"assign\">\u2714<\/span>Trusted Source<br \/><span class=\"refblack\">Factor XII signaling via uPAR-integrin \u00ce\u00b21 axis promotes tubular senescence in diabetic kidney disease<\/span><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-52214-8\" target=\"_blank\" rel=\"noopener noreferrer\">Go to source<\/a><\/p>\n<p><\/span><\/span>) <\/p>\n<p>A research team at the University of Leipzig Medical Center has now identified a signalling mechanism that causes damage to kidney cells. Coagulation factor FXII (F12), also known as Hageman factor, is involved in this process. <\/p>\n<p>\u201cIts production is increased in the body when blood sugar levels are high,\u201d says Ahmed Elwakiel, lead author of the study and scientist at the University of Leipzig Medical Center. Independent of its normal function in blood coagulation, FXII has a different effect on the tubular epithelial cells of the kidney: through a receptor mechanism, it forms a complex with two other proteins that have different functions in the body.  <\/p>\n<h2>A Molecular &#8220;On-Off Switch&#8221; Gone Wrong: The Link Between Diabetes and Kidney Disease<\/h2>\n<p>This complex acts like a molecular on-off switch. It sends a signal to produce more oxygen free radicals. This leads to oxidative stress and DNA damage in the cell. \u201cIn contrast to normal cell communication, however, the switch remains on under diabetic conditions; there is no pause button,\u201d says Ahmed Elwakiel. In the long term, the constantly increasing oxidative damage can neither be absorbed nor repaired. The kidneys then no longer function properly and the problem worsens over time. <\/p>\n<p>\u201cThe concentration of FXII correlates with the severity of the disease: the higher the value, the more damaged the kidney is. This makes the value a useful diagnostic marker,\u201d says the head of the Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics. FXII can be detected in the early stages of the disease and is therefore an important indicator of whether treatment is likely to be successful. <\/p>\n<p>To determine the <b>presence of FXII in the human organism and how it affects diabetes, the researchers analysed clinical values, kidney biopsies <\/b> and urine samples from several human cohorts, including the LIFE Adult Study from the Faculty of Medicine at Leipzig University and the HEIST-DiC cohort from Heidelberg University. <\/p>\n<p>The relationship between FXII and impaired kidney function was also clearly evident in mouse models: the scientists compared the kidney function of diabetic mice that produced FXII with that of mice in which they had temporarily blocked the production of FXII. \u201cThe kidney function of the mice that produced FXII was significantly worse,\u201d says Elwakiel. Furthermore, inhibiting FXII production in mice with clinical signs of kidney damage largely improved kidney function. The approach discovered by the scientists could therefore also have a therapeutic outcome in cases of established kidney damage. \u201cAnother approach would be to prevent the formation of the entire signalling complex,\u201d says the pharmacologist. In in vitro cell experiments, it was possible to stop the mechanism in this way. <\/p>\n<p><center><\/p>\n<p>Advertisement  <!-- rwd-common-middle -->      <\/p>\n<p><\/center> <\/p>\n<p>According to the authors of the study, no negative side effects on blood coagulation are to be expected from FXII inhibition. \u201cThe organism has various blood coagulation factors; it doesn\u2019t necessarily need FXII to initiate coagulation. We know from other studies that its inhibition does not result in increased bleeding risk,\u201d says Elwakiel.<\/p>\n<p><b>Reference:<\/b>&#13;<br \/>\n&#13;<br \/>\n&#13;\n<\/p>\n<ol class=\"list order-num\">\n<li>Factor XII signaling via uPAR-integrin \u03b21 axis promotes tubular senescence in diabetic kidney disease &#8211; <span class=\"breaktext\">(https:\/\/www.nature.com\/articles\/s41467-024-52214-8)<\/span><\/li>\n<\/ol>\n<p>Source-Eurekalert<\/p><\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.medindia.net\/news\/diabetic-kidney-disease-new-insights-revealed-217556-1.htm\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diabetic kidney disease, a serious complication of diabetes, is the leading cause of chronic kidney disease and kidney failure globally. This condition results in damage to the kidneys, affecting both their structure and function. (1\u2714&hellip;<\/p>\n<p><a class=\"excerpt-readmore\" href=\"https:\/\/rochellesthrezrs.com\/diabetic-kidney-disease-new-insights-revealed\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":122675,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-122674","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anxiety","odd"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/i0.wp.com\/rochellesthrezrs.com\/wp-content\/uploads\/2024\/10\/antibody-response-to-kidney-transplant.jpg?fit=1200%2C1000&ssl=1","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/posts\/122674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/comments?post=122674"}],"version-history":[{"count":0,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/posts\/122674\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/media\/122675"}],"wp:attachment":[{"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/media?parent=122674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/categories?post=122674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rochellesthrezrs.com\/wp-json\/wp\/v2\/tags?post=122674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}